Type: book
Abstract: Centel/a Asiatica has a reputation to restore declining cognitive function in traditional medicine. \nIn this study, asiatic acid from triterpenoids groups isolated from C. asiatica were examined for in vitro \nThin Layer Chromatography (TLC) by bioautographic acetylcholinesterase inhibitory activity, in vivo \npsycopharmacology of excitatory post synaptic potential (EPSP} on the rat hippocampus and in vivo \nlearning and memory potential as well as study of mechanism to the blood pressure with locomotors \nactivities. This study is consistent with asiatic acid which having an effect on TLC bioautographic \nacetylcholinesterase inhibitory activity with minimal inhibition concentration, 0.125 llll· In vivo \npsycopharmacology of EPSP was shown selectively to GABA B receptor agonist. Then the inhibitory \nconcentration was plotted using psycopharmacology of EPSP results with half maximal inhibitory \nconcentration was 14 11M with Hill-Coefficient 0.9828. The in vivo learning and memory potential were \nperformed using passive and active avoidance devices. Administration of asiatic acid facilitated on \npassive avoidance on memory but had no effect on active avoidance on learning. Study on mechanism \nto the blood pressure with locomotors performances shown that 10 dan 30 mg/k:g asiatic acid less \neffect in blood pressure and no sedative effect on locomotor performance.
Author: Abd Rahman, Izani Ghani
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7094327506