Year: 2015
Type: book
Abstract: Lymphovascular invasion comprising of blood vascular invasion and lymphatic \nvessel invasion has become one of the important existence in breast carcinoma. However, it is not clear which type of vascular invasion plays a major role in metastasis. \nThe aims of this study were to investigate the role of lymphatic and blood vessel \ninvasion, and lymphatic and microvessel density as prognostic biomarkers in 19 breast carcinoma patients. Immunohistochemical method was used where sections of breast carcinoma were stained with anti-D2-40 and anti-CD34 antibodies to evaluate lymphatic and blood vessel invasion respectively. Vascular invasion by \nimmunohistochemical method was compared with vascular invasion determined by \nhematoxylin & eosin (H&E) staining. Vascular invasion was also assessed by \ncorrelating with clinicopathological criteria. Vascular invasion was detected in 16 \n(84.2%) cases; 5/16 (31.3%) were lymphatic vessel invasion, 2/16 (72.5%) were blood \nvessel invasion and 9/16 (56.3%) showed both lymphatic and blood vessel invasion. \nIntratumoral lymphatic vessel invasion was significantly associated with tumor size \n(p=0.029), while peritumoral lymphatic vessel invasion was associated with distant \nmetastasis (p-0.018) and blood vessel invasion (p=0.024). These results suggest that \nvascular invasion in breast carcinoma predominantly occurs via lymphatic vessels and \nthe association of lymphatic invasion with distant metastasis provides evidence for their \nbiological importance in breast carcinoma. Hence, it is suggested that lymphatic \ninvasion be included in clinical practices as one of the potential prognostic biomarkers \nof breast carcinoma.
Author: Norhisham, Nur Fatiha
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7094365710