Gender difference in the effects of COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March–June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825–0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%
Authors: De Luca, Giuseppe, Manzo-Silberman, Stephane, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Busljetik, Oliver, Čerček, Miha, Okkels Jensen, Lisette, Loh, Poay Huan, Calmac, Lucian
Institutions: IRCCS Ospedale Galeazzi - Sant'Ambrogio, Azienda Ospedaliera Universitaria Policlinico "G. Martino", Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Bursa City Hospital, Universidade Federal de Pernambuco, Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences, Ss. Cyril and Methodius University in Skopje, Ljubljana University Medical Centre, Clinical Emergency Hospital Bucharest
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7094747980
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