Quantitative Analysis of Selected Pharmaceuticals Via Cerium (iv)-amaranth Dye Coupled Reaction
Year: 2025
Type: article
Abstract: Simple, sensitive, accurate, and precise spectrophotometric methods for quantitative determination of drugs, viz., Darifenacin (DAR), Esmolol Hydrochloride (ESM), Montelukast Sodium (MON), Sildenafil citrate (SIL),Terbinafine (TER) and Tramadol Hydrochloride (TRA) were developed. The method of each drug depends upon oxidation of drugs by Ce (IV) (Excess) and estimating the amount of unreacted Ce (IV) by amaranth dye at 523nm. The calibration curves obeyed Beer’s law over the concentration range of 1.4-7.0 µg ml-1 (DAR), 2-14 µg ml-1 (ESM), 2-10 µg ml-1 (MON), 20-70 µg ml-1 (SIL), 3-21 µg ml-1 (TER) & 2-14 µg ml-1 (TRA). The methods have been validated in terms of guidelines of ICH and applied to analysis of pharmaceuticals
Author: Sameera, Bano Ahmed Khan
Institution: Osmania University
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7094947034
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