Chronic Prescription of Renin-Angiotensin-Aldosterone System Inhibitors and Hospital Outcomes in Patients with Hypertension and COVID-19
Year: 2025
Type: article
Abstract: Kleber Aparecido De Oliveira, Tatiana Palotta Minari, Valquiria da Silva Lopes, Amanda Oliva Spaziani, Heloiza Duarte Dos Santos, Bianca Gasparino Rabelo, Letícia Aparecida Barufi Fernandes, Marco Aurélio de Almeida, Jessica Roma Uyemura, Marco Antonio Vieira-da-Silva, Juan Carlos Yugar-Toledo, Jose Fernando Vilela-Martin, Luciana Neves Cosenso-Martin Internal Medicine Department, State Medical School in Sao Jose Do Rio Preto (FAMERP), Sao Jose do Rio Preto, Sao Paulo, BrazilCorrespondence: Jose Fernando Vilela-Martin, Internal Medicine Department, State Medical School in Sao Jose Do Rio Preto (FAMERP) - Ave Brig, Faria Lima 5416, Sao Jose do Rio Preto – Sao Paulo, 15090-000, Brazil, Email [email protected]: A greater association of systemic arterial hypertension with worse prognosis in patients hospitalized with COVID-19 was described. Early in the pandemic, concerns were raised that the use of angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) could lead to unfavorable outcomes.Objective: To evaluate whether there is an association between the use of the ACEi and ARB medications with unfavorable outcomes in hypertensive patients hospitalized with COVID-19.Methods: This is a descriptive and retrospective study, collecting data through electronic medical records of patients with COVID-19 admitted to a University Hospital in 2020. Demographic data, use of ACEi or ARB medications, comorbidities, and outcomes, defined by the use of invasive ventilatory support (IVS), renal failure with progression to renal replacement therapy, and death were evaluated.Results: 700 medical records were analyzed, 374 were of hypertensive individuals. The mean age of the patients was 66 ± 14 years, 51% were male, and 89% were white. There was a significantly higher prevalence of hospital discharge among patients who received ACEi/ARB compared to those who did not take these medications, (p-value = 0.027). There was no statistically significant difference in the use of ACEi/ARB for IVS (p-value = 0.062) and for renal replacement therapy (p-value = 0.587).Conclusion: The use of ACEi/ARB drugs is not associated with worse outcomes in individuals with COVID-19. The present study demonstrated lower mortality rate associated with the use of these classes of drugs, similar to recent studies.Keywords: hypertension, COVID-19, angiotensin receptor blocker, angiotensin-converting enzyme inhibitor, hospital mortality
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7094977135
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