Work

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Year: 2003

Type: article

Abstract: Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.

Source: Science

DOI: 10.1126/science.1083328

Authors: Luca Santarelli, Michael Saxe, Cornelius Gross, Alexandre Surget, Fortunato Battaglia, Stephanie Dulawa, Noelia Weisstaub, James Lee, Ronald Duman, Ottavio Arancio, Catherine Belzung, René Hen

Institutions: Université de Tours, Yale University, New York University, Columbia University

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2148239264

FWCI: 39.38

Cites: 36

Cited by: 4,293

Related to: 10