Work

Planar Cell Polarity Signaling Pathway in Congenital Heart Diseases

Year: 2011

Type: review

Abstract: Congenital heart disease (CHD) is a common cardiac disorder in humans. Despite many advances in the understanding of CHD and the identification of many associated genes, the fundamental etiology for the majority of cases remains unclear. The planar cell polarity (PCP) signaling pathway, responsible for tissue polarity in Drosophila and gastrulation movements and cardiogenesis in vertebrates, has been shown to play multiple roles during cardiac differentiation and development. The disrupted function of PCP signaling is connected to some CHDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of CHD.

Source: BioMed Research International

DOI: 10.1155/2011/589414

Authors: Gang Wu, Jiao Ge, Xupei Huang, Yimin Hua, Dezhi Mu

Institutions: Sichuan University, West China Second University Hospital of Sichuan University, Florida Atlantic University, University of California, San Francisco

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680