Work

The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation

Year: 2003

Type: article

Abstract: This review outlines the mechanisms underlying the interaction between the nervous and immune systems of the host in response to an immune challenge. The main focus is the cholinergic anti-inflammatory pathway, which we recently described as a novel function of the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory response through interaction with peripheral a7 subunit-containing nicotinic acetylcholine receptors expressed on macrophages. We describe the modulation of systemic and local inflammation by the cholinergic anti-inflammatory pathway and its function as an interface between the brain and the immune system. The clinical implications of this novel mechanism also are discussed.

Source: Molecular Medicine

DOI: 10.1007/bf03402177

Authors: Valentin A. Pavlov, Hong Wang, Christopher J. Czura, Steven G. Friedman, Kevin J. Tracey

Institutions: Northwell Health, North Shore University Hospital

Language: English

Topic: Vagus Nerve Stimulation Research

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190