Work

Oxidation of ethanol in the brain and its consequences.

Year: 2006

Type: article

Abstract: Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetaldehyde following ethanol intake and the finding that even elevated acetaldehyde levels in the blood do not easily gain access to the brain. The recent discovery of the oxidation of ethanol to acetaldehyde in the adult brain may help explain the acute effects of ethanol.

Source: PubMed Central

Authors: Richard Deitrich, Sergey Zimatkin, Sergey Pronko

Institution: University of Colorado Anschutz

Language: English

Topic: Alcohol Consumption and Health Effects

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Alcohol Abuse and Alcoholism

Awards: ROLE OF ACETALDEHYDE IN CENTRAL ACTIONS OF ETHANOL, GENETICS OF LOW DOSE ETHANOL EFFECTS