Year: 2006
Type: article
Abstract: Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension. Area postrema (AP) lacks a blood-brain barrier and is a critical homeostatic integration center for humoral and neural signals. Here we investigate the role of AP in adiponectin signaling. We show that rat AP expresses AdipoR1 and AdipoR2 adiponectin receptor mRNA. We used current-clamp electrophysiology to investigate whether adiponectin influenced membrane properties of AP neurons and found that approximately 60% of rat AP neurons tested were sensitive to adiponectin. Additional electrophysiology experiments coupled with single-cell reverse transcription-PCR indicated that all neurons that expressed both subtypes of receptor were sensitive to adiponectin, whereas neurons expressing only one subtype were predominantly insensitive. Last, microinjection of adiponectin into AP caused significant increases in arterial blood pressure, with no change in heart rate, suggesting that adiponectin acts at AP to provide a possible link between control of energy homeostasis and cardiovascular function.
Source: Journal of Neuroscience
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Funders: Heart and Stroke Foundation of Canada, Crohn's and Colitis Foundation, Crohn's and Colitis Foundation of Canada, Canadian Association of Gastroenterology, Fondation pour la Recherche Médicale, Alberta Heritage Foundation for Medical Research, National Institutes of Health, Canadian Institutes of Health Research, National Institute of Diabetes and Digestive and Kidney Diseases
OpenAlex ID: W1978088424