Work

The Importance of Mitochondrial DNA in Aging and Cancer

Year: 2011

Type: article

Abstract: Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.

Source: Journal of Aging Research

DOI: 10.4061/2011/407536

Authors: Claus Desler, Maiken Lise Marcker, Keshav K. Singh, Lene Juel Rasmussen

Institutions: University of Copenhagen, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000