Work

The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans

Year: 2004

Type: article

Abstract: In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.

Source: Infection and Immunity

DOI: 10.1128/iai.72.12.7330-7333.2004

Authors: Chiatogu Onyewu, Floyd L. Wormley, John R. Perfect, Joseph Heitman

Institutions: Howard Hughes Medical Institute, Duke University, Duke Medical Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases