Year: 2010
Type: article
Study design: Observational Study
Abstract: Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of population stratification, corrected using one principal component, and some cryptic kinship that required no correction. NKAIN2 showed suggestive evidence of association with neuroticism as a main effect (p < 10(-6)) and GPC6 showed suggestive evidence for interaction with age (p approximately = 10(-7)). We found support for one previously-reported association (PDE4D), but failed to replicate other recent reports. These results suggest common SNP variation does not strongly influence neuroticism. Our study was powered to detect almost all SNPs explaining at least 2% of heritability, and so our results effectively exclude the existence of loci having a major effect on neuroticism.
Source: PLoS ONE
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study, G2957143966, Family study of specific subthreshold and threshold mood, anxiety, substance use and schizophrenia spectrum syndromes in the general population, Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based survey, G5531419334, G5599442719, G5735209081, G6715704539, G8253295407
OpenAlex ID: W2004855985