Work

Anillin Binds Nonmuscle Myosin II and Regulates the Contractile Ring

Year: 2004

Type: article

Abstract: We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation. We show that despite their interaction, anillin and myosin II are independently targeted to the contractile ring. Depletion of anillin in Drosophila or human cultured cells results in cytokinesis failure. Human cells depleted for anillin fail to properly regulate contraction by myosin II late in cytokinesis and fail in abscission. We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.e04-08-0758

Authors: Aaron F. Straight, Christine M. Field, Timothy J. Mitchison

Institutions: Stanford Medicine, Stanford University, Harvard University

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Damon Runyon Cancer Research Foundation, National Institute of General Medical Sciences

Award: Cytoskeleton polymerization dynamics in the cell cycle