Work

Contribution of NADPH-oxidase to the establishment of hippocampal neuronal polarity in culture

Year: 2015

Type: article

Abstract: Reactive oxygen species (ROS) produced by the NADPH oxidase (NOX) complex play important physiological and pathological roles in neurotransmission and neurodegeneration, respectively. However, the contribution of ROS to the molecular mechanisms involved in neuronal polarity and axon elongation is not well understood. In this work, we found that loss of NOX complex function altered neuronal polarization and decreased axonal length by a mechanism that involves actin cytoskeleton dynamics. These results indicate that physiological levels of ROS produced by the NOX complex modulate hippocampal neuronal polarity and axonal growth in vitro.

Source: Journal of Cell Science

DOI: 10.1242/jcs.168567

Authors: Carlos Wilson, M. Tulio Núñez, Christian González-Billault

Institution: University of Chile

Language: English

Topic: Axon Guidance and Neuronal Signaling

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1824485949

FWCI: 2.957

Cites: 38

Cited by: 68

Related to: 10