Work

At-Risk Populations for Osteosarcoma: The Syndromes and Beyond

Year: 2012

Type: article

Abstract: Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations. This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes.

Source: Sarcoma

DOI: 10.1155/2012/152382

Authors: George T. Calvert, R. Lor Randall, Kevin B. Jones, Lisa Cannon-Albright, Stephen Lessnick, Joshua D. Schiffman

Institutions: University of Utah, Huntsman Cancer Institute

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $820