Work

Nitric Oxide, Oxidative Stress, and p66Shc Interplay in Diabetic Endothelial Dysfunction

Year: 2014

Type: review

Abstract: Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among NO, reactive oxygen species (ROS), and one crucial regulator of intracellular ROS production, p66Shc protein.

Source: BioMed Research International

DOI: 10.1155/2014/193095

Authors: Alessandra Magenta, Simona Greco, Maurizio C. Capogrossi, Carlo Gaetano, Fabio Martelli

Institutions: Istituto Dermopatico dell'Immacolata, IRCCS Policlinico San Donato, Goethe University Frankfurt

Language: Latvian

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680