Year: 2010
Type: article
Abstract: Polycomb-group (PcG) proteins and associated histone modifications play pivotal roles in development, stem cell self-renewal and cancer. These proteins function in differ-ent transcriptional repressor complexes that epigenetically modify chromatin and participate in the establishment and maintenance of cell fates [1]. Although many proteins have been reported to associate with PcG protein complexes for transcriptional repression, the recent discovery of a link between long intergenic non-coding RNAs (lincRNAs) and PcG proteins added another regulatory layer for the diverse functions of PcG proteins [2, 3]. In a report published in a recent issue of Science [4], Tsai et al. further demonstrated that a lincRNA termed HOX Antisense Intergenic RNA (HOTAIR) not only functions as a molecular scaffold to link Polycomb repressive complexes 2 (PRC2) and lysine
DOI: 10.1093/abbs/gmq110
Authors: Lidong Sun, Jia Fang
Institution: Moffitt Cancer Center
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2158190679