Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.
Year: 1988
Type: article
Abstract: To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg).
Authors: R Bertini, M Bianchi, P Ghezzi
Institution: Mario Negri Institute for Pharmacological Research
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2160833615