Work

Effect of nitrite treatment on endothelial nitric oxide synthase in human left ventricle biopsy

Year: 2013

Type: article

Abstract: Acute myocardial infarction remains a major cause of morbidity and mortality worldwide. As such, there is a need for improved cardioprotective strategies. Nitrite represents an alternative source of bioactive nitric oxide (NO) particularly during hypoxia [1], and recent studies have demonstrated that nitrite is protective against myo-cardial ischemia reperfusion (I/R) injury [2]. Several mechanisms of nitrite bioconversion to NO have been proposed, such as xanthine oxidase [3], deoxyhaemoglobin and myoglobin [4], but the cytoprotective effects of nitrite therapy remains to be elucidated. Recent experimental data have shown that mice deficient in endothelial nitric oxide synthase (eNOS) exhibit reduced steady state levels of both plasma and cardiac nitrite levels when compared to the wild-type mice. Thus suggesting that nitrite restores

Source: BMC Pharmacology and Toxicology

DOI: 10.1186/2050-6511-14-s1-p3

Authors: Jenna Bailey, Sayqa Arif, Jorge Mascaro, Robert S Bonser, Michael P Frenneaux, Melanie Madhani

Institutions: University of Birmingham, Queen Elizabeth Hospital Birmingham, University of Aberdeen

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090