The SEARCH for Diabetes in Youth Study: Rationale, Findings, and Future Directions
Year: 2014
Type: review
Abstract: The SEARCH for Diabetes in Youth (SEARCH) study was initiated in 2000, with funding from the Centers for Disease Control and Prevention and support from the National Institute of Diabetes and Digestive and Kidney Diseases, to address major knowledge gaps in the understanding of childhood diabetes. SEARCH is being conducted at five sites across the U.S. and represents the largest, most diverse study of diabetes among U.S. youth. An active registry of youth diagnosed with diabetes at age <20 years allows the assessment of prevalence (in 2001 and 2009), annual incidence (since 2002), and trends by age, race/ethnicity, sex, and diabetes type. Prevalence increased significantly from 2001 to 2009 for both type 1 and type 2 diabetes in most age, sex, and race/ethnic groups. SEARCH has also established a longitudinal cohort to assess the natural history and risk factors for acute and chronic diabetes-related complications as well as the quality of care and quality of life of persons with diabetes from diagnosis into young adulthood. Many youth with diabetes, particularly those from low-resourced racial/ethnic minority populations, are not meeting recommended guidelines for diabetes care. Markers of micro- and macrovascular complications are evident in youth with either diabetes type, highlighting the seriousness of diabetes in this contemporary cohort. This review summarizes the study methods, describes key registry and cohort findings and their clinical and public health implications, and discusses future directions.
Source: Diabetes Care
DOI: 10.2337/dc14-0574
Institutions: Colorado School of Public Health, Wake Forest University Health Sciences, Wake Forest University, Cincinnati Children's Hospital Medical Center, Centers for Disease Control and Prevention, Kaiser Permanente, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, University of Washington, University of North Carolina at Chapel Hill, University of Hawaiʻi at Mānoa, Kuakini Medical Center, University of Hawaii System, Tecnológico de Monterrey
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Veterans Affairs, National Institutes of Health, U.S. Public Health Service, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Chronic Disease Prevention and Health Promotion, National Center for Advancing Translational Sciences
Awards: G1045936842, G1061576540, G1092462818, South Carolina Clinical & Translational Research Institute (SCTR), G1535104519, G1841928114, UCHSC Diabetes and Endocrinology Research Center, Colorado Clinical and Translational Science Institute (UL1), UNC Center for Diabetes Translation Research to Reduce Health Disparities, G2027946723, G2091809135, G22646245, G2320993242, G249568976, G2698360221, G2962638713, G3146357332, G3437629819, Institute of Translational Health Sciences, G3753588054, G3798223455, G4976965329, G5105936691, G561931883, Identifying urinary biomarkers for early type 2 diabetic nephropathy, G8005556827, G822274331, G832786732, G854732306, Cincinnati Center for Clinical and Translational Sciences and Training, G874743574, G891215646, Nutrition Obesity Research Center (NORC), G951231213
OpenAlex ID: W2058667229