Regulatory Role of G Protein–Coupled Estrogen Receptor for Vascular Function and Obesity

Year: 2009

Type: article

Abstract: We found that the selective stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from cardiovascular disease and obesity.

Source: Circulation Research

DOI: 10.1161/circresaha.108.190892

Institutions: University of Zurich, University Hospital Zurich, Temple University, The University of Texas Southwestern Medical Center

Language: English

Topic: Estrogen and related hormone effects

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Neurological Disorders and Stroke

Awards: A novel intracellular 7TM estrogen receptor in breast, Development of GPR30-Selective Ligands, G207119517, Pathomechanisms of cardiovascular injury in obesity, Activity of brainstem neurons, Activity of Preganglionic Neurons in Vitro, ACTIVITY OF PREGANGLIONIC NEURONS IN VITRO, Pulmonary Vasoreactivity Following Chronic Hypoxia, The Role of GPR30 in Advanced Endometrial Cancer, Nitric Oxide-Mediated Pulmonary Vasodilation After Chronic Hypoxia, Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neurons

OpenAlex ID: W2140002693