Year: 2010
Type: article
Abstract: Insulin resistance is a key feature of type 2 diabetes, and the strong association between fat oversupply and defective insulin action in target tissues, especially skeletal muscle and liver, has motivated the search for intracellular lipid mediators that can interfere with insulin signaling and glucose homeostasis. Two of the best-studied candidates are diacylglycerol (DAG) and ceramide (1–3), to the extent that the tissue levels of these intermediate species are now routinely measured in models of insulin resistance and in human studies. Correlative evidence for their roles has accumulated over the last 10–15 years, but unfortunately, there are now several conflicting reports concerning the relative importance of these molecules (4–7). To resolve this situation, it is necessary to go beyond descriptive studies in order to
Source: Diabetes
DOI: 10.2337/db10-0912
Author: Carsten Schmitz-Peiffer
Institutions: Garvan Institute of Medical Research, UNSW Sydney
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2073053958