Work

Powering the Immune System: Mitochondria in Immune Function and Deficiency

Year: 2014

Type: review

Abstract: Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. Recent observations of immune dysfunction and increased incidence of infection in patients with primary mitochondrial disorders further support an important role for mitochondria in the proper function of the immune system. Here we review current findings.

Source: Journal of Immunology Research

DOI: 10.1155/2014/164309

Authors: Melissa A. Walker, Stefano Volpi, Katherine B. Sims, Jolan E. Walter, Elisabetta Traggiai

Institutions: Massachusetts General Hospital, University of Genoa, Novartis (Switzerland), Novartis Institutes for BioMedical Research

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,830