Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes
Year: 2011
Type: article
Abstract: Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals. Fecal communities clustered into enterotypes distinguished primarily by levels of Bacteroides and Prevotella. Enterotypes were strongly associated with long-term diets, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella). A controlled-feeding study of 10 subjects showed that microbiome composition changed detectably within 24 hours of initiating a high-fat/low-fiber or low-fat/high-fiber diet, but that enterotype identity remained stable during the 10-day study. Thus, alternative enterotype states are associated with long-term diet.
Source: Science
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Dietary Patterns and the Course of Inflammatory Bowel Disease, Institutional Clinical and Translational Science Award, Predoctoral Training in Signaling and Cellular Regulation, Immune modulation by intestinal cell differentiation, Diet, Genetic Factors, and the Gut Microbiome in Crohn's Disease, Purchase of the Roche GS SLX Sequencing System, Predoctoral Training Program in Signaling and Cellular Regulation, Center for Molecular Studies in Digestive and Liver Diseases
OpenAlex ID: W1968105193