Work

A liaF Codon Deletion Abolishes Daptomycin Bactericidal Activity against Vancomycin-Resistant Enterococcus faecalis

Year: 2013

Type: article

Abstract: The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00021-13

Authors: Jose M. Munita, Truc T. Tran, Lorena Diaz, Diana Panesso, Jinnethe Reyes, Barbara E. Murray, Cesar A. Arias

Institutions: Universidad del Desarrollo, Clínica Alemana, University of Houston, The University of Texas Health Science Center at Houston, Universidad El Bosque

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Astellas Pharma, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Molecular Mechanisms Of Daptomycin Resistance In Enterococci, Enterococcus faecium virulence: A molecular and therapeutic approach, G6387671297, Alternative Approaches for E. faecalis Infections

OpenAlex ID: W2163046019

FWCI: 5.228

Cites: 12

Cited by: 69

Related to: 10