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Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

Year: 2013

Type: article

Abstract: The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.

Source: Journal of Virology

DOI: 10.1128/jvi.01562-13

Authors: Xinrong Tao, Terence E. Hill, Chikao Morimoto, Clarence J. Peters, Thomas G. Ksiazek, Chien-Te K. Tseng

Institutions: The University of Texas Medical Branch at Galveston, Juntendo University

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Erasmus Medisch Centrum, Japan Society for the Promotion of Science, Erasmus+, National Institute of Allergy and Infectious Diseases