Year: 1999
Type: article
Abstract: et al. (1) report on the identification of a cytokine, the macrophage migration inhibitory factor or MIF, that overcomes p53 function by suppressing its transcriptional activity, thus linking complex programs that govern proinflammatory response and cell fate. p53 has a key role in the regulation of cell growth and death, and its involvement in these regulatory systems may reflect its ability to respond to different cellular stress situations by inducing cell cycle arrest or apoptosis (see references 2–4 for reviews on the topic and below for more details on p53 function). When altered by germ line or somatic mutations, by aberrant patterns of expression, or through the inactivating potential of Mdm2 or certain viral oncoproteins, loss of wild-type p53 function is responsible for tumorigenesis and tumor progression (5–7). The relationship between certain chronic inflammatory conditions
Authors: Carlos Cordon-Cardo, Carol Prives
Institutions: Memorial Sloan Kettering Cancer Center, Columbia University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1989014517