Work

Negative Association Between Schizophrenia and Rheumatoid Arthritis

Year: 1991

Type: review

Abstract: Persuasive evidence has accumulated demonstrating a strong negative association between rheumatoid arthritis and schizophrenia at the population level. Explanations for this phenomenon have taken into consideration immunological, biochemical, and genetic factors. In this article, we examine these and other factors in closer detail. We then propose hypotheses at the molecular level that might account for the negative association between the two diseases. These hypotheses may provide clues for our colleagues in molecular biology as they search for candidate genes, "anti-genes," and molecular mechanisms relevant to schizophrenia.

Source: Schizophrenia Bulletin

DOI: 10.1093/schbul/17.4.669

Authors: S. Vinogradov, I. I. Gottesman, H. W. Moises, S. Nicol

Institutions: California Pacific Medical Center, University of Virginia, University Hospital Schleswig-Holstein, Hennepin County, Hennepin County Medical Center

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2140764717