Year: 2008
Type: article
Abstract: The loss of functional redundancy is the key process in the evolution of duplicated genes. Here we systematically assess the extent of functional redundancy among a large set of duplicated genes in Saccharomyces cerevisiae. We quantify growth rate in rich medium for a large number of S. cerevisiae strains that carry single and double deletions of duplicated and singleton genes. We demonstrate that duplicated genes can maintain substantial redundancy for extensive periods of time following duplication ( approximately 100 million years). We find high levels of redundancy among genes duplicated both via the whole genome duplication and via smaller scale duplications. Further, we see no evidence that two duplicated genes together contribute to fitness in rich medium substantially beyond that of their ancestral progenitor gene. We argue that duplicate genes do not often evolve to behave like singleton genes even after very long periods of time.
Source: PLoS Genetics
Institution: Stanford University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,043
Awards: G1763076811, G4083725591, Cellular and Molecular Biology Training Program, Population Analysis of all Transposable Elements in the Sequenced Drosophila Genome, COMPUTATIONAL METHODS FOR PROTEOMIC ANALYSIS, Revolutionizing Biomedical and Clinical Research through Innovative Technology, Patterns of background nucleotide substitution in the human lineage, Institutional Training Grant in Genome Science
OpenAlex ID: W1999880514