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Metallo-β-Lactamase-Producing Bacteroides Species Can Shield Other Members of the Gut Microbiota from Antibiotics

Year: 2014

Type: article

Abstract: Antibiotics disrupt the intestinal microbiota, rendering patients vulnerable to colonization by exogenous pathogens. Intermicrobial interactions may attenuate this effect. Incubation with ceftriaxone-resistant, ccrA-positive, β-lactamase-producing Bacteroides strains raised the minimum bactericidal concentration of ceftriaxone required to kill a susceptible Escherichia coli strain (mean change, <0.25 to 29 mg/liter; P = 0.009); incubation with ceftriaxone-resistant but non-β-lactamase-producing Bacteroides strains had no effect. The production of β-lactamase by common members of the intestinal microbiota (Bacteroides) can protect susceptible fellow commensals from β-lactams.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.03719-14

Authors: Usha Stiefel, Mary Ann Tima, Michelle M. Nerandzic

Institutions: Louis Stokes Cleveland VA Medical Center, Case Western Reserve University

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Microbiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2034506148

FWCI: 0.568

Cites: 19

Cited by: 33

Related to: 10