Year: 2007
Type: article
Abstract: Standard systemic therapy for breast cancer treatment and prevention are generally directed at reduction in cell growth and increase in apoptosis by direct inhibition of DNA synthesis or signalling pathways that control cell proliferation and cell death. Data are accumulating that calorie restriction (CR) and/or exercise, or agents that target metabolic pathways may have antitumour effects either alone or in combination with standard therapies for cancer prevention and treatment, and merit further investigation. Here, we outline evidence concerning the effectiveness of this approach. The first observation, that energy restriction could retard tumour growth, was reported nearly 100 years ago [1]. More recently, Dirx and colleagues [2] conducted a meta-analysis of 14 studies of the effect of calorie restriction on spontaneous mammary tumour development in mice and
Source: Breast Cancer Research
DOI: 10.1186/bcr1825
Author: Anthony Howell
Institutions: University of Manchester, The Christie Hospital
Language: English
Topic: Dietary Effects on Health
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
OpenAlex ID: W2150038279