Clinical Relevance of the Serum Dipeptidyl Peptidase IV (DPP IV/CD26) Activity in Adult Patients with Crohn's Disease and Ulcerative Colitis*
Year: 2005
Type: article
Study design: Observational Study
Abstract: Dipeptidyl peptidase IV (DPP IV/CD26), a serine-type protease, is a membrane-anchored enzyme widely expressed in many cell types.DPP IV is also present in a soluble form in the serum.The aim of this study was to evaluate the clinical relevance of the changes in serum DPP IV activity in adult patients with inflammatory bowel diseases -IBD (Crohn's disease -CD and Ulcerative colitis -UC).Both serum DPP IV activities in patients with CD (36.8±1.5 mmol min -1 dm -3 ) and UC (33.9±2.1 mmol min -1 dm -3 ) were statistically significantly decreased compared to healthy controls (48.4±1.1 mmol min -1 dm -3 ), (P<0.001).The values correlated inversely with the disease severity for both diseases.No statistically significant difference in the serum DPP IV activity in patients with CD and UC was found and therefore it cannot be a good marker for a differential diagnosis.However, it appears to be useful as an available non-invasive marker in the diagnosis of disease activity. Keywords• dipeptidyl peptidase IV (DPP IV/CD26) • inflammatory bowel disease • Crohn's disease • ulcerative colitis * Dedicated to Professor @eljko Ku}an on the occasion of his 70 th birthday.
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2208950209