Studies in Steroid Metabolism. Xxvii. a Comparison of the Steroid Response to Acth and Cortisone in Normal Young Men 1
Year: 1955
Type: article
Abstract: This study deals with the isolation and quan-titative estimation of urinary ketosteroids follow-ing the administration of adrenocorticotrophic hormone (ACTH) and cortisone acetate to two normal young men, with appropriate control studies of their endogenous steroid excretion. The study was undertaken to obtain information on several aspects of endocrine physiology. The first of these was to provide an acceptable com-parison for an investigation of the influence of stress upon the young male subject as measured by the output of steroid hormone metabolites. The second was to secure basic information re-lating to the nature of the adrenal response and the metabolic pathways utilized when the adrenal gland was stimulated by its trophic hormone as well as when the pituitary secretion was sup-pressed by the administration of large doses of exogenous steroid. The third was to obtain data after intravenously administered ACTH for com-parison with the several studies in which much larger amounts of this hormone were administered by the intramuscular route. The fourth was to obtain evidence from related metabolic experi-ments on single individuals, serving as their own controls, to test the several generalizations that have been made concerning the metabolic fate of steroid hormones. While the design of the studies and the methods employed provide information upon these topics, it should be emphasized that in certain respects the amount of hormone ad-ministered has been in the pharmacologic range and the end products studied constitute only a portion of the total metabolites.
DOI: 10.1172/jci103208
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: American Cancer Society
OpenAlex ID: W2139494198