Work

Variability in laboratory parameters used for management of Cushing’s syndrome

Year: 2015

Type: review

Abstract: The progress in assay methodology, from the use of radioactive tracers to chemiluminescent signals, from competitive to chromatographic techniques and from serum or urine to saliva has considerably impacted on hormonal measurements. The clinician now may choose among multiple tests but the inherent variability in cortisol and ACTH secretion, coupled to lack of harmonization among assay procedures and normal ranges mandates careful interpretation of any result. The present review will examine factors which affect interpretation of cortisol and ACTH measurements and their impact on tests used for management of Cushing's syndrome.

Source: Endocrine

DOI: 10.1007/s12020-015-0676-9

Authors: Francesca Pecori Giraldi, Alberto G. Ambrogio

Institutions: University of Milan, IRCCS Istituto Auxologico Italiano

Language: English

Topic: Pituitary Gland Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,090