Work

Synaptic Plasticity and Translation Initiation

Year: 2004

Type: preprint

Abstract: It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA. Therefore, regulation of translation initiation is likely to be intimately involved in modulating synaptic strength. Our understanding of the translation-initiation process has expanded greatly in recent years. In this review, we discuss various aspects of translation initiation, as well as signaling pathways that might be involved in coupling neurotransmitter and neurotrophin receptors to the translation machinery during various forms of synaptic plasticity.

Source: Learning & Memory

DOI: 10.1101/lm.79004

Authors: Eric Klann, Marcia D. Antion, Jessica L. Banko, Lingfei Hou

Institution: Baylor College of Medicine

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze

Funders: FRAXA Research Foundation, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Award: G1383089530