Work

Through the Looking Glass: Differential Noradenergic Modulation of Prefrontal Cortical Function

Year: 2000

Type: review

Abstract: Ghosts rising off the lakeIn to moonlight In between Never so alive Norepinephrine (NE) facilitates the functioning of many brain areas, otten by increasing "signals" relative to "noise".In most brain regions, NE enhances neural processing through actions at beta and alpha-1 adrenergic receptors.This review will provide a brief overview of the receptor mechanisms influencing subcortical and posterior cortical functions and contrast these actions with the very different mechanisms by which NE modulates the working memory functions of the prefrontal cortex (PFC; Fig. 1). BETA-AND ALPHA-I-ADRENOCEPTOR STIMULATION ENHANCE POSTERIOR CORTICAL AND SUBCORTICAL FUNCTIONSNE has widespread effects on arousal state, stimulus processing, and plasticity including long-term memory consolidation.Most of these NE actions involve beta adrenergic mechanisms, although alpha-1 receptor stimulation also has important effects on excitability and cortical

Source: Neural Plasticity

DOI: 10.1155/np.2000.133

Author: Amy F. T. Arnsten

Institution: Yale University

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,830

Funder: National Institute on Aging