Oestrogen plus progestin increased coronary heart disease and breast cancer in postmenopausal women
Year: 2003
Type: article
Abstract: Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA2002 ; 288 : 321 –33 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In postmenopausal women, what are the risks and benefits of oestrogen plus progestin use, particularly with respect to coronary heart disease (CHD) events? Randomised (allocation concealed), blinded (clinicians, participants, data collectors, outcome assessors, and monitoring committee), placebo controlled trial with a mean 5.2 years of follow up. 40 US clinical centres. 16 608 postmenopausal women who were 50–79 years of age (mean age 63.3 y) with an intact uterus at baseline. Exclusion criteria included medical conditions associated with probable survival of <3 years, previous breast cancer or other cancer in the past 10 years (except non-melanoma skin cancer), low hematocrit or … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.aulast%253DWriting%2BGroup%2Bfor%2Bthe%2BWomen%2527s%2BHealth%2BInitiative%2BIn%26rft.auinit1%253D%2B%26rft.volume%253D288%26rft.issue%253D3%26rft.spage%253D321%26rft.epage%253D333%26rft.atitle%253DRisks%2Band%2BBenefits%2Bof%2BEstrogen%2BPlus%2BProgestin%2Bin%2BHealthy%2BPostmenopausal%2BWomen%253A%2BPrincipal%2BResults%2BFrom%2Bthe%2BWomen%2527s%2BHealth%2BInitiative%2BRandomized%2BControlled%2BTrial%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.288.3.321%26rft_id%253Dinfo%253Apmid%252F12117397%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.288.3.321&link_type=DOI [3]: /lookup/external-ref?access_num=12117397&link_type=MED&atom=%2Febnurs%2F6%2F1%2F20.atom [4]: /lookup/external-ref?access_num=000176807000024&link_type=ISI
Source: Evidence-Based Nursing
DOI: 10.1136/ebn.6.1.20
Author: Cathy Kessenich
Institution: University of Tampa
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2010938610