Work

Novel roles for JNK1 in metabolism

Year: 2010

Type: article

Abstract: Activation of stress-kinase signaling has recently been recognized as an important pathophysiological mechanism in the development of diet-induced obesity, type 2 diabetes mellitus and other aging-related pathologies. Here, c-Jun N-terminal Kinase (JNK) 1 knockout mice have been shown to exhibit protection from diet-induced obesity, glucose intolerance, and insulin resistance. Nonetheless, the tissue-specific role of JNK1-activation in the development of the metabolic syndrome has been poorly defined so far. Recently, it was demonstrated that JNK1 signaling plays a crucial role in the central nervous system (CNS) and in the pituitary to control systemic glucose and lipid metabolism partially through regulation of hormones involved in growth and energy expenditure.

Source: Aging

DOI: 10.18632/aging.100192

Authors: Bengt F. Belgardt, Jan Mauer, Jens C. Brüning

Institutions: University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Max Planck Institute for Biology of Ageing

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Eli Lilly and Company, European Foundation for the Study of Diabetes, Deutsche Forschungsgemeinschaft, Fritz Thyssen Stiftung