Work

Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?

Year: 2015

Type: article

Abstract: The notion that central nervous system (CNS) insulin action plays an important role in mediating the inhibition of endogenous glucose production (EGP) is becoming increasingly accepted (1–5). In the rodent, insulin’s effect in the brain involves transport of insulin across the blood–brain barrier, activation of insulin signaling, open-ing of neuronal ATP-sensitive potassium (KATP) channels, signaling via vagal hepatic efferents, phosphorylation of liver STAT3, and suppression of gluconeogenic gene ex-pression, with subsequent reduction of EGP due to inhi-bition of gluconeogenesis but not glycogenolysis (6–10). The effect was relatively slow in onset (requiring several hours to appear) and was evident under nonphysiological circumstances because infusion of insulin into a peripheral vein results in absolute or relative hepatic insulin defi-

Source: Diabetes

DOI: 10.2337/db14-1666

Authors: Dale S. Edgerton, Alan D. Cherrington

Institution: Vanderbilt University

Language: English

Topic: Pancreatic function and diabetes

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases