Work

Mutation of the PIK3CA oncogene in human cancers

Year: 2006

Type: review

Abstract: It is now well established that cancer is a genetic disease and that somatic mutations of oncogenes and tumour suppressor genes are the initiators of the carcinogenic process. The phosphatidylinositol 3-kinase signalling pathway has previously been implicated in tumorigenesis, and evidence over the past year suggests a pivotal role for the phosphatidylinositol 3-kinase catalytic subunit, PIK3CA, in human cancers. In this review, we analyse recent reports describing PIK3CA mutations in a variety of human malignancies, and discuss their possible implications for diagnosis and therapy.

Source: British Journal of Cancer

DOI: 10.1038/sj.bjc.6602970

Authors: B Karakas, K E Bachman, B H Park

Institutions: Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, University of Maryland, Baltimore, Johns Hopkins Medicine, Johns Hopkins Hospital

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190