Year: 2011
Type: article
Abstract: Caffeoylquinic acid (CQA) derivatives are natural functional compounds isolated from a variety of plants and possess a broad range of pharmacological properties, including antioxidant, hepatoprotectant, antibacterial, antihistaminic, anticancer, and other biological effects [1]. Recently, it has been demonstrated that CQA derivatives possess neuroprotective effects in Ab-induced PC12 cell toxicity and in tetrahydropapaveroline (THP)induced C6 glioma cell death [2]. One of the animal models that is used to study AD and aging is the senescence-accelerated mouse (SAM). The SAM model was developed in 1981, which originally consisted of nine major senescence-accelerated-prone mice (SAMP) substrains and three major senescence-accelerated-resistant mice (SAMR) substrains, each of which exhibits the characteristic disorders. Methodology As in vitro experiment, the human neuroblastoma clonal SH-SY5Y cell were maintained at 37°C under 5 % CO 2 / 95 % air. As in vivo experiment, the CQA-treated mice were orally administered with 3,5-di-O-CQA mixed with drinking water (6.7 mg/kg · day) for 1 month using oral administration tube and syringe. Proteomics analysis, real-time PCR, measurement of intracellular ATP content, Moris water maze were carried out to investigate the neuroprotective effect of CQA.
Source: BMC Proceedings
Authors: Junkyu Han, Hiroko Isoda
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,290
OpenAlex ID: W2032048971