Work

Microbial Translocation and Infectious Diseases: What Is the Link?

Year: 2012

Type: editorial

Abstract: Copyright © 2012 Gabriella d’Ettorre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The lumen of the gastrointestinal (GI) tract is a complex ecosystem where an enormous quantity of different bacterial species, termed the microbiota, establishes a generally sym-biotic relationship with host immune system and epithelial cells. The correct interaction of the components of the GI tract permits the normal function of this ecosystem, reduces the risk of an excess of microbial translocation (MT) from the lumen of GI tract to the systemic circulation, and prevents its systemic consequences such as immune activation. From the historical observations of Berg and Garlington who defined bacterial translocation as “the passage of viable bacteria through the epithelial mucosa

Source: International Journal of Microbiology

DOI: 10.1155/2012/356981

Authors: Gabriella D'Ettorre, Daniel Douek, Mirko Paiardini, Giancarlo Ceccarelli, Vincenzo Vullo

Institutions: Sapienza University of Rome, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Vaccine Research Center, Emory University

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000