Year: 2015
Type: review
Abstract: In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.
Source: Molecular Neurodegeneration
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,090
Awards: ApoE Receptor Biology and Neurodegeneration, Translating CD33 genetic mechanism into a novel Alzheimers therapeutic, Preclinical assessment of an ABCA1 agonist as a novel therapeutic for AD, Potential ApoE Isoform-Specific Detrimental Effects of RXR Agonists in Alzheimer', Statistical Genetics Methods for Mixed Pathologies, Genomic Editing to Elucidate CD33 Function, TLR4 antagonists as a therapeutic treatment for APOE-modulated neuroinflammation
OpenAlex ID: W2119581346