African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts
Year: 2012
Type: article
Study design: Observational Study
Abstract: The risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that genetic factors may explain some of this population difference in disease risk. However, relatively few genetic studies have examined this hypothesis in a large sample of African Americans with and without diabetes. Therefore, we performed an admixture analysis using 2,189 ancestry-informative markers in 7,021 African Americans (2,373 with type 2 diabetes and 4,648 without) from the Atherosclerosis Risk in Communities Study, the Jackson Heart Study, and the Multiethnic Cohort to 1) determine the association of type 2 diabetes and its related quantitative traits with African ancestry controlling for measures of SES and 2) identify genetic loci for type 2 diabetes through a genome-wide admixture mapping scan. The median percentage of African ancestry of diabetic participants was slightly greater than that of non-diabetic participants (study-adjusted difference = 1.6%, P<0.001). The odds ratio for diabetes comparing participants in the highest vs. lowest tertile of African ancestry was 1.33 (95% confidence interval 1.13-1.55), after adjustment for age, sex, study, body mass index (BMI), and SES. Admixture scans identified two potential loci for diabetes at 12p13.31 (LOD = 4.0) and 13q14.3 (Z score = 4.5, P = 6.6 × 10(-6)). In conclusion, genetic ancestry has a significant association with type 2 diabetes above and beyond its association with non-genetic risk factors for type 2 diabetes in African Americans, but no single gene with a major effect is sufficient to explain a large portion of the observed population difference in risk of diabetes. There undoubtedly is a complex interplay among specific genetic loci and non-genetic factors, which may both be associated with overall admixture, leading to the observed ethnic differences in diabetes risk.
Source: PLoS ONE
Institutions: Johns Hopkins University, National University of Singapore, Singapore Eye Research Institute, Duke-NUS Medical School, Broad Institute, Harvard University, University of Southern California, Jackson State University, The University of Texas Health Science Center at Houston, Massachusetts General Hospital, Tougaloo College, University of Mississippi Medical Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: Johns Hopkins University, Ministerio de Economía y Competitividad, National Institutes of Health, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center on Minority Health and Health Disparities, National Institute on Minority Health and Health Disparities
Awards: G1045430581, G118440752, G1238898755, JACKSON HEART STUDY, G1325221871, G136105103, G1407109571, G1798569254, G2021590520, G2050560213, Atherosclerosis Risk in Communities Study (ARIC), G215333750, Diabetes Research and Training Center, G2513955590, CCSP FIELD CENTER, G2562080342, G25881238, COMMUNITY AND COHORT SURVEILLANCE PROGRAM, CENTRAL HEMOSTATIS LABORATORY FOR CCSP, JACKSON HEART STUDY, GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS, GENOTYPING FOR LOCATING HUMAN DISEASE GENES, G3157549237, G3186385431, G3216861457, G3236609591, G3497998071, Multiethnic Cohort Study of Diet and Cancer, G3648845612, G3667269547, G390162502, G3906407906, NHLBI DNA Re-sequencing and Genotyping Program -- Genotyping Center, G4145745212, G4176762999, MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER, G4407166175, Atherosclerosis Risk in Communities Study (ARIC), G4587988226, G4671189754, G49077879, G4932516547, G5026578359, Population structure in whole-genome disease scans, G528395701, G5302475043, G5359555627, G538503247, G5451084504, G5522185877, Genetic Susceptibility to Cancer in Multiethnic Cohorts, G5654214539, Atherosclerosis Risk in Communities Study (ARIC), G5780424650, G6203107232, G6204895930, Genetic Epidemiology of NAFLD and T2DM, G6576172577, G6860406196, Health Disparities and CVD: Admixture Mapping in the Jackson Heart Study, G786153652, G793702358, G812579647, Admixture Mapping to Identify T2DM Genes in African Americans, G831158291, G8486527673, G9000015747, G9000028264, G9000036580, G9000074493, G9000077244, G9000080822, G9000108254, G9000126117, G9000136955, G9000152345, G9000216949, G9000286278, G9000294209, G9000304106, JACKSON HEART STUDY, Atherosclerosis Risk in Communities Study (ARIC)
OpenAlex ID: W2162666754