Work

Rat traps: filling the toolbox for manipulating the rat genome

Year: 2010

Type: review

Abstract: The laboratory rat is rapidly gaining momentum as a mammalian genetic model organism. Although traditional forward genetic approaches are well established, recent technological developments have enabled efficient gene targeting and mutant generation. Here we outline the current status, possibilities and application of these techniques in the rat.

Source: Genome biology

DOI: 10.1186/gb-2010-11-9-217

Authors: Ruben van Boxtel, Edwin Cuppen

Institutions: University Medical Center Utrecht, Hubrecht Institute for Developmental Biology and Stem Cell Research, Cancer Genomics Centre

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,490

OpenAlex ID: W2112188586

FWCI: 0.218

Cites: 67

Cited by: 15

Related to: 10