Impact of Sirt1 on mammalian aging
Year: 2010
Type: article
Abstract: Studies in yeast, flies and worms have indicated that overexpression of the protein deacetylase Sir2 increases longevity [1]. Mammals possess 7 paralogs of the Sir2 gene, being Sirt1 the most similar one closest to Sir2 [1]. In our recent work [2], we have used a genetic approach to address the effect of Sirt1 on mammalian ageing. In particular, we have generated two independent lines of transgenic mice that globally overexpress Sirt1 (≈3-fold) under the control of its own regulatory elements (Sirt1-tg mice). Previously, we had shown that these Sirt1-tg mice are protected from the metabolic damage associated to high-fat diet (HFD) through the inhibition of NFκB inflammatory pathway and the activation of PGC1α antioxidant response [3]. The potent beneficial effects of Sirt1 in protecting from
Source: Aging
Authors: Daniel Herranz, Manuel Serrano
Institution: Spanish National Cancer Research Centre
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2179271106