Enumerating β-Cells in Whole Human Islets: Sex Differences and Associations With Clinical Outcomes After Islet Transplantation
Year: 2015
Type: article
Study design: Observational Study
Abstract: Islet transplantation is an experimental therapy for type 1 diabetes. Though it is increasingly successful, limitations in-clude unpredictable declines in islet graft function (1). There is still inade-quate knowledge of specific human is-let characteristics that predispose to successful and durable islet graft func-tion and what types of donors are more likely to have islets with these benefi-cial traits. The relationship between the composition of dissociated human is-lets (as opposed to whole islets) and transplant outcomes has been studied (2), with a positive association between
Source: Diabetes Care
DOI: 10.2337/dc15-0723
Authors: Enza Marchese, Caitlin Rodeghier, Rebecca S. Monson, Benjamin McCracken, Tingqi Shi, Wesley Schrock, Joan Martellotto, Jose Oberholzer, Kirstie K. Danielson
Institution: University of Illinois Chicago
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2177887995