Year: 2007
Type: review
Abstract: There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently present antigen to T cells, produce soluble factors, including cytokines and chemokines, and form B cell aggregates in the target organ of rheumatoid arthritis. In this review we analyze the multifaceted role that B cells play in the pathogenesis of rheumatoid arthritis and discuss how this information can be used to guide more specific targeting of B cells for the therapy of this disease.
Source: Arthritis Research & Therapy
DOI: 10.1186/ar2125
Authors: Claudia Mauri, Michael R Ehrenstein
Institution: University College London
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,690
Funder: Versus Arthritis
Award: G688168316
OpenAlex ID: W2101010293