Work

Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study

Year: 2009

Type: article

Abstract: The notion of uncontrollable stress causing reduced hippocampal size remains controversial in the posttraumatic stress disorder literature, because human studies cannot discern the causality of effect. Here, we addressed this issue by using structural magnetic resonance imaging in rats to measure the hippocampus and other brain regions before and after stress. Chronic restraint stress produced approximately 3% reduction in hippocampal volume, which was not observed in control rats. This decrease was not signficantly correlated with baseline hippocampal volume or body weight. Total forebrain volume and the sizes of the other brain regions and adrenal glands were all unaffected by stress. This longitudinal, within-subjects design study provides direct evidence that the hippocampus is differentially vulnerable and sensitive to chronic stress.

Source: Neuroreport

DOI: 10.1097/wnr.0b013e328332bb09

Authors: Taekwan Lee, Tim Jarome, Shi-Jiang Li, Jeansok J. Kim, Fred J. Helmstetter

Institutions: University of Wisconsin System, University of Wisconsin–Milwaukee, Medical College of Wisconsin, University of Washington

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Mental Health